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PIN1 inhibitor API-1
CAS No. 680622-70-2
PIN1 inhibitor API-1 ( —— )
产品货号. M24694 CAS No. 680622-70-2
PIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM). PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from the nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1596 | 有现货 |
|
| 10MG | ￥3029 | 有现货 |
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| 25MG | ￥4334 | 有现货 |
|
| 50MG | ￥6261 | 有现货 |
|
| 100MG | ￥8076 | 有现货 |
|
| 200MG | ￥11826 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称PIN1 inhibitor API-1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM). PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from the nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development.
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产品描述PIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM). PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from the nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase domain and effectively inhibits Pin1 cis-trans isomerizing activity.
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同义词——
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通路Others
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靶点Other Targets
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受体Pin1
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研究领域——
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适应症——
化学信息
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CAS Number680622-70-2
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分子量366.3
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分子式C15H13F3N6O2
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纯度>98% (HPLC)
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溶解度DMSO:250 mg/mL (682.50 mM; Need ultrasonic)
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SMILESC1=CC(=CC=C1CNC(=O)C(F)(F)F)COC2=NC(=NC3=C2NC=N3)N
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Pu W, et al. Targeting Pin1 by inhibitor API-1 regulates microRNA biogenesis and suppresses hepatocellularcarcinoma development. Hepatology. 2018 Aug;68(2):547-560.
产品手册
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